Your mission

• Develop and optimize lipid nanoparticle (LNP) formulations for the delivery of nucleic acids (DNA, and DNA nanostructures).
• Design and perform experiments to improve LNP encapsulation efficiency, stability, and payload integrity, including analytical methods (e.g. DLS, zeta potential, RiboGreen assay).
• Integrate bioconjugation strategies (e.g., lipid-/DNA-antibody, -peptide, -polymer conjugates) for targeted delivery applications, including purification and analytical methods (e.g., FPLC, HPLC, LC-MS, gel electrophoresis).
• Troubleshoot formulation and analytical challenges and contribute innovative solutions to advance R&D projects.
• Coordinate with internal and external partners to support project progress and knowledge exchange.
• Document experimental procedures and results, and present findings to internal stakeholders and external collaborators.

Your profile

 

• Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences, Nanotechnology, or a related field.
• Practical experience in LNP formulation and characterization, ideally with nucleic acid payloads.
• Solid knowledge of analytical techniques such as DLS, zeta potential, HPLC, LC-MS, and gel electrophoresis.
• Experience with bioconjugation methods (antibodies, DNA, peptides, or polymers) is a strong plus.
• Strong problem-solving skills, attention to detail, and the ability to work independently as well as in a team.
• Excellent communication skills in English (oral and written).
• A valid work permit for Germany.

Why CPTx

• Innovative Environment: Work with a team of experts in a vibrant start-up culture, pushing the boundaries of biotech innovation. 
• Impactful Work: Contribute to cutting-edge technology that has the potential to revolutionize healthcare.
• Growth Opportunities: Gain hands-on experience in the world of biotech start-ups. Work together with leading scientists.
• Unbounded Potential: As we rapidly expand our team, seize the opportunity for accelerated growth and early responsibility.
• Your well-being: Urban Sports Club membership.

About us

At CPTx, we are pioneering single-stranded DNA technology and manufacturing processes to engineer advanced therapies faster and more reliably than ever before.
Founded in 2021 in Munich, Germany, and now also with offices in South San Francisco, California, we set out to translate more than 15 years of foundational research at the Technical University of Munich into novel therapeutics. Merging science and engineering, we leverage programmable DNA-based fabrication technologies to create novel multi-modal drugs that include targetable delivery functionalities.

Our leadership team includes high profile academic and industry experts, enabling us to address disease challenges across genetic, infectious, and autoimmune diseases fields.
https://www.cptx.bio/